Which option correctly states how D-Dimer levels relate to age?

• A. Normal D-Dimer levels decrease with age
• B. Normal D-Dimer levels increase with age
• C. D-Dimer levels are unchanged by age
• D. D-Dimer testing is not affected by age in any way

Answer: (D)

D-dimer interpretation changes with age because baseline levels tend to rise as people get older. A fixed cutoff (like the standard universal threshold) becomes less specific in older adults, leading to more false positives. To address this, many guidelines use age-adjusted thresholds for patients over 50—for example, using roughly age in years × 10 μg/L as the cutoff. This keeps the test sensitive for ruling out venous thromboembolism while reducing false positives in older patients. So, stating that D-dimer testing is not affected by age isn’t accurate; age influences the interpretation and is accommodated with age-adjusted cutoffs.